Welcome to the Kastrup Lab. We are a group of biochemists and engineers working to gain a deeper upstanding of how blood clotting is regulated and can be controlled therapeutically. Severe hemorrhage is a major cause of death, particularly among young people, while thrombosis is a major contributor to death and disability with age. We use proteins and cells naturally involved in blood clotting to develop novel technologies for addressing unmet needs in controlling severe bleeding and preventing unwanted clotting.
The research in our lab is focused on these questions:
- What new technologies are needed to halt bleeding in the most severe cases of hemorrhage?
- Can platelets be genetically modified to enhance their hemostatic activity, or targeted to treat Alzheimer’s disease?
- Can clot stability be altered to treat hemorrhage or thrombosis?
- Do soil and microbes in wounds influence bleeding?
We use a variety of biochemical assays, RNA biotechnology, biomaterial synthesis, imaging, patient blood, microfluidics and human blood, and small and large animal models to answer these questions.