TOMORROW’S HEMOSTATIC THERAPIES

FROM TODAY’S RESEARCH

Publications

A list of biomedical-related publications can also be viewed here

2019

37. Topical tranexamic acid is more effective when formulated with self-propelling particles.

Baylis JR, Lee MM, St. John AE, Wang X, Simonson E, Cau M, Kazerooni A, Gusti V, Statz ML, Yoon JSJ, Liggins RT, White NJ, Kastrup CJ.

J Thromb Haemost, Accepted 05-2019.

36. Delivery of mRNA to Platelets using Lipid Nanoparticles.

Novakowski SK, Jiang K, Prakash G, Kastrup CJ.  

Scientific Reports, 2019: 9, 552.

2018

35. Coagulation Factors XIII-A and XIII-A* Decrease In Some DVT Patients Following Catheter-directed Thrombolysis.

Hur WS, Warner H, Machan L, Kastrup CJ.

Blood Coagulation and Fibrinolysis, ePub ahead of print, 2018-10.

34. Coagulation Factor XIIIa can Crosslink Amyloid β into Dimers and Oligomers and to Blood Proteins.

Hur WS, Mazinani N, Lu XJD, Yefet LS, Byrnes JR, Ho L, Yeon JH, Filipenko S, Wolberg AS, Jefferies WA, Kastrup CJ.

Journal of Biological Chemistry(SA), Accepted and In Press, 2018-11.

33. Rivaroxaban and Apixaban Induce Clotting Factor Xa Fibrinolytic Activity.

R.L.R. Carter, K. Talbot, W.S. Hur, S.C. Meixner, J.G. Van Der Guten, D.T. Holmes, H.C.F. Cote, C.J. Kastrup, T.W. Smith, A.Y.Y. Lee, E.L.J. Pryzdial.

J Thromb Haemost 2018; 16(11): 2276-2288.

32. Platelets loaded with liposome‐encapsulated thrombin have increased coagulability.

Chan V, Sarkari M, Sunderland R, St. John AE, White NJ, Kastrup CJ.

J Thromb Haemost 2018; 16: 1226–1235.

In the News

Team modifies platelets to improve coagulation”, Hematology Times, Apr. 13, 2018.

“Look! Down in the petri dish! It’s a super platelet!”, UBC Faculty of Medicine, Apr. 11, 2018, (Also reposted on Apr. 12, 2018 – Science Daily).

2017

Jan. 14, 2017 – Bowen Island Undercurrent

Local researcher developing new technology to stop post-partum bleeding”.

30. Localization of short-chain polyphosphate enhances its ability to clot flowing blood plasma.

J.H. Yeon, N. Mazinani, T.S. Schlappi, K.Y.T. Chan, J.R. Baylis, S.A. Smith, A.J. Donovan, D. Kudela, G.D. Stucky, Y. Liu, J.H. Morrissey, C.J. Kastrup.

Scientific Reports, 2017: 7: 42119.

2016

Dec. 6, 2016 – UBC Faculty of Medicine

Christian Kastrup wins Banting Award from True Patriot Love Foundation” by Brian Kladko.

29. Thrombolysis by chemically modified coagulation factor Xa.

E.L. Pryzdial, S.C. Meixner, K. Talbot, L.J. Eltringham-Smith, J.R. Baylis, F.M. Lee, C.J. Kastrup, W.F. Sheffield.

Journal of Thrombosis and Haemostasis,  2016: 14(9): 1844-1854.

28. Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid.

J.R. Baylis, A. Finkelstein-Kulka, L. Macias-Valle, J. Manji, M. Lee, E. Levchenko, C. Okpaleke, S. Al-Salihi, A. Javer, C.J. Kastrup.

The Laryngoscope, 2016: 127(4): 787-793.

In the News

Dec. 6, 2016 – UBC Faculty of Medicine

An ‘effervescing’ coagulant shows promise in the operating room” by Bryan Kladko

27. Halting hemorrhage with self-propelling particles and local drug delivery.

J.R. Baylis, K.Y.T. Chan, C.J. Kastrup.

Thrombosis Research, 2016: 141(Suppl 2): S26-S39

26. Adhesion of blood clots can be enhanced when copolymerized with a macromer that is cross-linked by coagulation factor XIIIa.

K.Y.T. Chan, C.Y. Zhao, E.M.J. Siren, J.C.Y. Chan, J. Boschman, C.J. Kastrup.

Biomacromolecules, 2016: 17(6): 248–2252.

In the News

Jul. 15, 2016 – UBC Faculty of Science, UBC Faculty of Medicine

UBC researchers in vent a synthetic ‘glue’ for blood clots” by Bryan Kladko

25. Self-propelled dressings containing thrombin and tranexamic acid improve short-term survival in a swine model of lethal junctional hemorrhage.

J.R. Baylis, A.E. St. John, X. Wang, E.B. Lim, M.L. Statz, E. Simonson, S.A. Stern, R.T. Liggins, N.J. White, C.J. Kastrup.

Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, 2016: 46(3 Suppl 1): 123-128.

2015

24. Coagulation Factor XIIIa is Inactivated by Plasmin.

W.S. Hur, N. Mazinani, X.J.D. Lu, H.M. Britton, J.R. Byrnes, A.S. Wolberg, C.J. Kastrup.

Blood, 2015: 126(20): 2329-2337.

In the News

Nov. 12, 2015 – Blood Commentaries

D.H. Farrell, “Lucky 13”, Blood, 126(20):2261-2. doi: 10.1182/blood-2015-09-670471.

23. Controlled transcription of exogenous mRNA in platelets using protocells.

V. Chan, S.K. Novakowski, S. Law, C. Klein-Bosgoed, C.J. Kastrup.

Angewandte Chemie, 2015: 54(46):13590–13593.

In the News

UBC makes leap with blood cells”, Vancouver 24 hrs (local newspaper), Nov. 12, 2015

Platelets engineered to deliver, transcribe RNA”, Science & Enterprise, Nov. 5, 2015

UBC researchers transform humble blood cells into ‘Franken-platelets’” EurekAlert!, Nov. 4, 2015

Behold UBC’s latest creation: the “Frankenplatelet”, UBC Faculty of Medicine, Nov. 4, 2015

22. Self-Propelling Particles that Transport Cargo Through Flowing Blood and Halt Hemorrhaging.

J.R. Baylis, J.H. Yeon, M.H. Thomson, A. Kazerooni, X Wang, A.E. St. John, E.B. Lim, D. Chien, A. Lee, J.Q. Zhang, J.M. Piret, L.S. Machan, T.F. Burke, H.J. White, C.J. Kastrup.

Science Advances, 2015: 1(9), e1500379.

In the News
Dec. 17, 2015 – Vancouver Sun Self-propelled particles deliver clotting drugs in spite of heavy blood flow” by Randy Shore Nov. 12, 2015 – BioCentury Innovations Self-propelling particles go upstream into wounds to stop bleeding” by Karen Tkach Oct. 8, 2015 – Naked Scientists (Podcast) Blood clotting ‘bullets’ Oct. 6, 2015 – CTV Canada AM UBC researchers develop powder to stop bleeding” reported by Marci Ien Oct. 4, 2015 – News 1130 UBC develops blood clotting powder” reported Martin Macmahon Oct. 3, 2015 – Global News BC BC researchers develop powder that stops the bleeding” reported by Jon Azpiri Oct. 2, 2015 – CKNW AM980 The first of its kind: UBC creates powder to stop critical bleeding” reported by Shelby Thom Oct. 2, 2015 – WIRED Gas-Propelled Microparticles Could Stop Bleeding in Wounds

21. A biochemical network can control formation of a synthetic material by sensing numerous specific stimuli.

J.H. Yeon, K.Y.T. Chan, T.C. Wong, K. Chan, M. R. Sutherland, R.F. Ismagilov, E.L.G. Pryzdial, C.J. Kastrup.

Scientific Reports, 2015: (5):10274.

2014

20. Defects in phosphate acquisition and storage influence the virulence of Cryptococcus neoformans.

Kretschmer, E. Reiner, G. Hu, N. Tam, D.L. Oliveira, M. Caza, J.H. Yeon, J. Kim, C.J. Kastrup, W.H. Jung. J.W. Kronstad.  

Infection and Immunity, 2014: 2697-2712.

2012

Nov 23, 2012 – UBC Faculty of Medicine

“UBC Inventor of Self-Propelled Coagulant Wins Grant from Grand Challenges Canada” by Brian Kladko

19. Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot.

C.J. Kastrup, M. Nahrendorf, J.L. Figueiredo, H. Lee, S. Kambhampati, T. Lee, S.W. Cho, R. Gorbatov, Y. Iwamoto, T.T. Dang, P. Dutta, J.H. Yeon, H. Cheng, C.D. Pritchard, A.J. Vegas, C.D. Siegel, S. MacDougall, M. Okonkwo, J.R. Stone, A.J. Coury, R. Weissleder, R. Langer, D.G. Anderson.

Proceedings of the National Academy of Sciences. 2012 (109): 21444-9.

In the News

Mar/Apr 2013 – ACCN (Canadian Chemical News)

Mussel ‘glue’ protects damaged­ blood vessels” by Tyler Irving

Jan. 11, 2013 – Science

Editor’s Choice: “Vascular Glue” by Paula A. Kiberstis

Jan. 8, 2013 — Wonder of Science (an online magazine for high school students)

“Mussel glue makes blood vessel glue”

Jan. 2, 2013 – Science Translational Medicine

Editor’s Choice: “Bioinspired Glue for Healing Atherosclerotic Plaques” by Carsten Skarke

Dec. 12, 2012 – Global News (aired on 6 pm BC News Hour nation-wide)

“Researchers from UBC have adapted the adhesive quality from shoreline mussels into a gel for medical use” reported by Leigh Kjekstad

Dec 10, 2012 – UBC Faculty of Medicine (also featured by UBC Faculty of Science)

A mussel’s stickiness inspires invention of an adhesive gel for blood vessels” by Brian Kladko

18. Remotely-activated Protein-Producing Nanoparticles.

Schroeder, M.S. Goldberg, C.J. Kastrup, Y. Wang, B.J. Joseph, C.G. Levins, R. Langer, D.G. Anderson.

Nano Letters, 2012 (12):2685-2689.

17. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics.

Cheng, M. Byrska-Bishop, C.T. Zhang, C.J. Kastrup, N.S. Hwang, W.W. Lee, X. Xu, M.P. Nahrendorf, R. Langer, D.G. Anderson.

Biomaterials, 2012 (33): 5004-12.

16. Rapid Discovery of Potent siRNA-Lipid-Nanoparticles Enabled by Controlled Microfluidic Formulation.

Chen, K. Love, Y. Chen, A. Eltoukhy, C.J. Kastrup, Christian; G. Sahay, A. Jeon, D. Yizhou, K. Whitehead, D.G. Anderson.

Journal of the American Chemical Society, 2012 (134): 6948-6951.

2010

15. Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery.

Cheng, C.J. Kastrup, R. Ramanathan, D.J. Siegwart, M.L. Ma, S.R. Bogatyrev, Q.B. Xu, K.A. Whitehead, R. Langer, D.G. Anderson.

ACS Nano, 2010 (4): 625-631.

2009

14. Confinement Regulates Complex Biochemical Networks: Initiation of Blood Clotting by “Diffusion Acting”.

  1. Shen, C.J. Kastrup, R.R. Pompano, R.F. Ismagilov.

Biophysical Journal, 2009 (97): 2137-2135.

2008

13. Spatial Localization of Bacteria Controls Initiation of Blood Coagulation by “Quorum Acting”

C.J. Kastrup, J.Q. Boedicker, A.P. Pomerantsev, M. Moayeri, Y. Bian, R.R. Pompano, T.R. Kline, F. Shen, W.-J. Tang, S.H. Leppla, R.F. Ismagilov.

Nature Chemical Biology, 2008 (4): 742-750.

12. Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries is Controlled by Shear Rate.

Shen, C.J. Kastrup, Y. Liu, R.F. Ismagilov.

Arteriosclerosis Thrombosis and Vascular Biology, 2008 (28): 2035-2041.

11. The Effects of Shear Rate on Propagation of Blood Clotting Determined Using Microfluidics and Numerical Simulations.

M.K. Runyon, C.J. Kastrup, B. Johnson-Kerner, T.G. Van Ha, R.F. Ismagilov.

Journal of the American Chemical Society, 2008 (130): 3458-3464.

10. Using Microfluidics to Understand the Effect of Spatial Distribution of Tissue Factor on Blood Coagulation.

Shen, C.J. KastrupR.F. Ismagilov.

Thrombosis Research, 2008 (121) S27-S30. 

2007

09. A physical-organic mechanistic approach to understanding the complex reaction network of hemostasis (blood clotting).

C.J. Kastrup, R.F. Ismagilov.

Journal of Physical Organic Chemistry, 2007 (20): 711-715.

08. Using Chemistry and Microfluidics to Understand the Spatial Dynamics of Complex Biological Networks.

C.J. Kastrup, M.K. Runyon, E.M. Lucchetta, R.F. Ismagilov.

Accounts of Chemical Research, 2007 (41): 549-558.

07. Characterization of the Threshold Response of Initiation of Blood Clotting to Stimulus Patch Size.

C.J. Kastrup, F. Shen, R.F. Ismagilov.

Biophysical Journal, 2007 (93): 2969-2977.

06. Simple Chemistry Identifies Mechanism for Localization of Blood Clots in Complex Network of Hemostasis.

M.K. Runyon, B. Johnson-Kerner, C.J. Kastrup, T.G. Van Ha, R.F. Ismagilov.

Journal of the American Chemical Society, 2007 (129): 7014-7015.

05. Response to shape emerges in a complex biochemical network and its simple chemical analogue.

C.J. Kastrup, F.Shen, R.F. Ismagilov.

Angewandte Chemie International Edition, 2007 (46): 3660-3662.

2006

04.  Modular Chemical Mechanism Predicts Spatiotemporal Dynamics of Initiation in the Complex Network of Hemostasis.

C.J. Kastrup, M.K. Runyon, F.Shen, R.F. Ismagilov.

Proceedings of the National Academy of Sciences, 2006 (103): 15747-15752.

2002

03. The aromaticity and Möbius characteristics of carbeno[8] heteroannulenes and triplet state annulenes.

C.J. Kastrup, S.V. Oldfield, H.S. Rzepa.

Chemical Communications, 2002 (6): 642-643.

02. An ab initio computational study of monodentate palladium ligand complexes with Mobius-aromatic chiral character.

C.J. Kastrup, S.V. Oldfield, H.S. Rzepa.

Journal of the Chemical Society-Dalton Transactions, 2002 (12): 2421-2422.

01. Möbius aromatic forms of 8-pi electron heteropine.

W.L. Karney, C.J. Kastrup, S.V. Oldfield, H.S. Rzepa.

Journal of the Chemical Society-Perkin Transactions 2, 2002 (3): 388-392.