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The Kastrup Lab is a multidisciplinary group of biochemists and engineers who investigate the biochemical and biophysical processes that regulate blood clotting and use their discoveries to develop novel therapeutics for hemostasis and thrombosis.

PUBLICATIONS & FUNDING

HOW YOUR FUNDING IS MAKING AN IMPACT

RESEARCH GRANTS

PUBLICATIONS & PATENTS

2022

  • US Department of Defense - JWMRP
  • NIH R01 (Co-I)
  • Advancing a Healthier Wisconsin
  • American Heart Association

2022

  • Nature Communications (Accepted and In Press)
  • Journal of Trauma and Acute Care Surgery
  • Journal of Military, Veteran and Family Health
  • Journal of Thrombosis and Haemostasis
  • Endoscopy International Open
  • Molecular Pharmaceutics
  • Injury
  • Blood
  • Military Medicine
  • Nature Cardiovascular Research
  • Spin-out company: SeraGene Therapeutics
  • PCT patent on antifibrinolytic RNA-LNP
  • Provisional patent on mRNA for rare bleeding
  • Provisional patent on PAI-1

2021

  • NIH R01 (Co-I)
  • Nanomedicines Innovation Network-SI
  • MITACS
  • US Department of Defense - RDTRA
  • CIHR Project Grant

2021

  • Science
  • Extreme Mechanics Letters
  • Transfusion
  • Journal of Thrombosis and Haemostasis
  • Endoscopy Open International
  • Provisional patent on RNA-edited platelets
  • Provisional patent on ADAMTS13

2020

  • US Department of Defense - MuLTI
  • US Department of Defense - PRMRP
  • Nanomedicines Innovation Network
  • CFI John R. Evans Leaders Fund

2020

  • Blood
  • Endoscopy Open International
  • Journal of Thrombosis and Haemostasis
  • Blood Advances
  • Scientific Reports
  • Res Pract Thromb Haemost
  • Blood Advances
  • ACS Nano
  • Biochemistry
  • Provisional patent on RNA-edited platelets
  • Provisional patent on ADAMTS13

2019

  • Bayer Hemophilia Award

2019

  • J. Thromb. & Haem.
  • Scientific Reports
  • Patent issued on hemostatic particles

2018

  • NSERC Discovery Grant

2018

  • Blood Coag. & Fibrin.
  • J. Biol. Chemistry
  • J. Thromb. & Haem.
  • J. Thromb. & Haem.
  • Provisional patent on antithrombotic siRNA

2017

  • Novo Access to Insight

2017

  • Scientific Reports
  • Ann. Rev. of Biochem.
  • Laryngoscope
  • Provisional patent on liposomal thrombin
  • Spin-out company: CoMotion

2016

  • CFI John R. Evans Leaders Fund

2016

  • J. Thromb. & Haem.
  • Shock
  • Thrombosis Research
  • Biomacromolecules

RESEARCH GRANTS

PUBLICATIONS & PATENTS

2018

2018

  • Scientific Reports
  • Blood Coag. & Fibrin.
  • J. Biol. Chemistry
  • J. Thromb. & Haem.
  • J. Thromb. & Haem.

2017

  • NSERC Discovery Grant

2017

  • Scientific Reports
  • Ann. Rev. of Biochem.
  • Laryngoscope

2016

  • CFI John R. Evans Leaders Fund
  • Novo Access to Insight

2016

  • J. Thromb. & Haem.
  • Shock
  • Thrombosis Research
  • Biomacromolecules

2015

  • CIHR Foundation Scheme
  • MSFHR Scholar Award

2015

  • Angew. Chem. Int. Ed
  • Blood
  • Science Advances
  • Scientific Reports
Steve, PhD                            Amy, PhD Candidate

What’s New

Nov 2022- 2022 has been an exciting year with lots of awards for students and post docs, as well as, grant funding, spin-off companies, and publications. We will update them all soon! 

Oct 2022- Congratulations to Lih Jin Juang, and Amy Wong-Strilchuk for graduating with their PhDs in Biochemistry and Molecular Biology! 

Apr 2021 – Well done to Amy Strilchuk for her CIHR CGS Doctoral Award, and to Madelaine Robertson and Colton Strong for their CIHR CGS Master’s Awards! 

Mar 2021 – The Kastrup lab is awarded a CIHR Project Grant! 

Jan 2021 – Welcome to Dr. Katie Badior and Dr. Adele Khavari, two new postdocs starting in our lab. Katie will be co-supervised by Dr. Eric Jan. Welcome back to Alyssa Yong, who started as an undergrad in our lab and is now a research technician.

Nov 2020 – New Publication “Post-Translational Modifications of Platelet-Derived Amyloid Precursor Protein by Coagulation Factor XIII-A*” accepted in Biochemistry.

Sep 2020 – Welcome to our two new graduate students, Madelaine Robertson and Colton Strong, who will be co-supervised by Dr. Pieter Cullis and Dr. Dana Devine, respectively.

Sep 2020 – Congratulations to Massimo Cau for his SBME GSI Entrance Award, and to Lih Jiin Juang for her UBC 4-year fellowship!

Sep 2020 – The Kastrup lab is awarded two US Department of Defense grants!

Aug 2020 – The Kastrup lab is looking for a new postdoc! More details on ‘Contact Us’ page.

Jul 2020 –  New publication “Sustained Depletion of FXIII-A by Inducing  Acquired FXIII-B Deficiency” accepted in Blood.

Jul 2020 –  Congratulations to Dr. Nima Mazinani who successfully defending his PhD!

Jun 2020 – New publication “Bleeding is increased in amyloid precursor protein knockout mouse” in Res Pract Thromb Haemost.

May 2020 – Well done to Jerry Leung for receiving the NSERC Postgraduate Scholarships Doctoral Award (PGS-D)!

Apr 2020 – Media coverage on our publication “Coagulation Factor XII Contributes to Hemostasis When Activated by Soil in Wounds” is released through various media outlets.

Apr 2020 – New publication “Coagulation Factor XII Contributes to Hemostasis When Activated by Soil in Wounds” in Blood Advances.

Apr 2020 – Well done to Dr. Jayesh Kulkarni for being awarded the Nanomedicines Innovation Network (NMIN) Postdoctoral Fellowship Award in Gene Therapy!

Apr 2020 – Well done to Amy Strilchuk for being awarded the William and Dorothy Gilbert Scholarships in Bio-Medical Sciences Award!

Apr 2020 – Congratulations to Jerry Leung, who successfully passed his Comprehensive Exam!