The Kastrup Lab is a multidisciplinary group of biochemists and engineers who investigate the biochemical and biophysical processes that regulate blood clotting. They use their discoveries to develop novel therapeutics for hemostasis and thrombosis based on RNA gene therapies, cellular therapies and nanomedicines.
PUBLICATIONS & FUNDING
HOW YOUR FUNDING IS MAKING AN IMPACT
RESEARCH GRANTS
PUBLICATIONS & PATENTS
2023
- NIH R01 (PI)
- NIH R01 (MPI)
2023
- Science Advances (In Press)
- Military Medicine
- Gastrointestinal Endoscopy
- Provisional Patent on mRNA delivery using platelet transfusions
2022
- US Department of Defense - JWMRP
- NIH R01 (Co-I)
- Advancing a Healthier Wisconsin
- American Heart Association
2022
- Nature Communications
- Journal of Trauma and Acute Care Surgery
- Journal of Military, Veteran and Family Health
- Journal of Thrombosis and Haemostasis
- Endoscopy International Open
- Molecular Pharmaceutics
- Injury
- Blood
- Military Medicine
- Nature Cardiovascular Research
- Spin-out company: SeraGene Therapeutics
- PCT patent on antifibrinolytic RNA-LNP
- Provisional patent on mRNA for rare bleeding
- Provisional patent on PAI-1
2021
- NIH R01 (Co-I)
- Nanomedicines Innovation Network-SI
- MITACS
- US Department of Defense - RDTRA
- CIHR Project Grant
2021
- Science
- Extreme Mechanics Letters
- Transfusion
- Journal of Thrombosis and Haemostasis
- Endoscopy Open International
- Provisional patent on RNA-edited platelets
- Provisional patent on ADAMTS13
2020
- US Department of Defense - MuLTI
- US Department of Defense - PRMRP
- Nanomedicines Innovation Network
- CFI John R. Evans Leaders Fund
2020
- Blood
- Endoscopy Open International
- Journal of Thrombosis and Haemostasis
- Blood Advances
- Scientific Reports
- Res Pract Thromb Haemost
- Blood Advances
- ACS Nano
- Biochemistry
- Provisional patent on RNA-edited platelets
- Provisional patent on ADAMTS13
2019
- Bayer Hemophilia Award
2019
- J. Thromb. & Haem.
- Scientific Reports
- Patent issued on hemostatic particles
2018
- NSERC Discovery Grant
2018
- Blood Coag. & Fibrin.
- J. Biol. Chemistry
- J. Thromb. & Haem.
- J. Thromb. & Haem.
- Provisional patent on antithrombotic siRNA
2017
- Novo Access to Insight
2017
- Scientific Reports
- Ann. Rev. of Biochem.
- Laryngoscope
- Provisional patent on liposomal thrombin
- Spin-out company: CoMotion
2016
- CFI John R. Evans Leaders Fund
2016
- J. Thromb. & Haem.
- Shock
- Thrombosis Research
- Biomacromolecules
RESEARCH GRANTS
PUBLICATIONS & PATENTS
2018
2018
- Scientific Reports
- Blood Coag. & Fibrin.
- J. Biol. Chemistry
- J. Thromb. & Haem.
- J. Thromb. & Haem.
2017
- NSERC Discovery Grant
2017
- Scientific Reports
- Ann. Rev. of Biochem.
- Laryngoscope
2016
- CFI John R. Evans Leaders Fund
- Novo Access to Insight
2016
- J. Thromb. & Haem.
- Shock
- Thrombosis Research
- Biomacromolecules
2015
- CIHR Foundation Scheme
- MSFHR Scholar Award
2015
- Angew. Chem. Int. Ed
- Blood
- Science Advances
- Scientific Reports
60
Publications
8.5
Avg. impact factor
7
Graduate Students
(currently)
3
PDFs (currently)
38
Fellowships
& Awards
60
Undergrads
Mentored
16
Patents Filed
Steve, PhD Amy, PhD Candidate
What’s New
Fall 2023- We’ve had an exciting fall in the Kastrup Lab!
Congratulations to our team for a new publication in Science Advances.
We’ve also had several trainee led grants awarded! Way to go, Francesca and Laura for the Joan Cox Gill Pilot Award and Katherine for the Transfusion Medicine, Vascular Biology and Cell Therapy Program Research Staff/Trainee-led Pilot Grant
May 2023- A big month for awards in the Kastrup Lab! Congratulations to Dr. Amy Strilchuk for being named a 2023 Schmidt Science Fellow, and to Francesca Ferraresso and Colton Strong for receiving CIHR Canada Graduate Scholarships for their doctoral programs!
Apr 2023- Congratulations to Massimo Cau for successfully defending his PhD thesis! New Publication- “Ruggedized Self-Propelling Hemostatic Gauze Delivers Low Dose of Thrombin and Systemic Tranexamic Acid and Achieves High Survival in Swine with Junctional Hemorrhage.” accepted in Military Medicine
Mar 2023- Manoj Paul is joining the Versiti lab from the University of British Columbia! Welcome Manoj! New Publication- “Self-Propelling trombin powder enebles gemostasis with no observable rebleeding or thrombosis over three days in a procine model of upper gastrointestinal bleeding” accepted in Gastrointestinal Endoscopy.
Feb 2023-Visiting PhD student Matteo Ferraresso joins the Versiti lab from the University of British Columbia. Welcome Matteo!
Jan 2023- Research Trainee, Amanda Wietrzny, was accepted into the interdisciplinary Program at the Medical College of Wisconsin for Fall 2023. She will be pursuing her PhD in Biochemistry. Good luck, Amanda!
Nov 2022- 2022 has been an exciting year with lots of awards for students and post docs, as well as, grant funding, spin-off companies, and publications.
Oct 2022- Congratulations to Lih Jin Juang, and Amy Wong-Strilchuk for graduating with their PhDs in Biochemistry and Molecular Biology!
Apr 2021 – Well done to Amy Strilchuk for her CIHR CGS Doctoral Award, and to Madelaine Robertson and Colton Strong for their CIHR CGS Master’s Awards!
Mar 2021 – The Kastrup lab is awarded a CIHR Project Grant!
Jan 2021 – Welcome to Dr. Katie Badior and Dr. Adele Khavari, two new postdocs starting in our lab. Katie will be co-supervised by Dr. Eric Jan. Welcome back to Alyssa Yong, who started as an undergrad in our lab and is now a research technician.
Nov 2020 – New Publication “Post-Translational Modifications of Platelet-Derived Amyloid Precursor Protein by Coagulation Factor XIII-A*” accepted in Biochemistry.
Sep 2020 – Welcome to our two new graduate students, Madelaine Robertson and Colton Strong, who will be co-supervised by Dr. Pieter Cullis and Dr. Dana Devine, respectively.
Sep 2020 – Congratulations to Massimo Cau for his SBME GSI Entrance Award, and to Lih Jiin Juang for her UBC 4-year fellowship!
Sep 2020 – The Kastrup lab is awarded two US Department of Defense grants!
Aug 2020 – The Kastrup lab is looking for a new postdoc! More details on ‘Contact Us’ page.
Jul 2020 – New publication “Sustained Depletion of FXIII-A by Inducing Acquired FXIII-B Deficiency” accepted in Blood.
Jul 2020 – Congratulations to Dr. Nima Mazinani who successfully defending his PhD!
Jun 2020 – New publication “Bleeding is increased in amyloid precursor protein knockout mouse” in Res Pract Thromb Haemost.
May 2020 – Well done to Jerry Leung for receiving the NSERC Postgraduate Scholarships Doctoral Award (PGS-D)!
Apr 2020 – Media coverage on our publication “Coagulation Factor XII Contributes to Hemostasis When Activated by Soil in Wounds” is released through various media outlets.
Apr 2020 – New publication “Coagulation Factor XII Contributes to Hemostasis When Activated by Soil in Wounds” in Blood Advances.
Apr 2020 – Well done to Dr. Jayesh Kulkarni for being awarded the Nanomedicines Innovation Network (NMIN) Postdoctoral Fellowship Award in Gene Therapy!
Apr 2020 – Well done to Amy Strilchuk for being awarded the William and Dorothy Gilbert Scholarships in Bio-Medical Sciences Award!
Apr 2020 – Congratulations to Jerry Leung, who successfully passed his Comprehensive Exam!
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