A list of biomedical-related publications can also be viewed here.

30. R.R. Pompano, A.H. Chiang, C.J. Kastrup, R.F. Ismagilov, “Conceptual and experimental tools to understand spatial effects and transport phenomena in nonlinear biochemical networks illustrated with patchy switching”, Annual Review of Biochemistry, 2017: 86. doi:10.1146/annurev-biochem-060815-014207 [Full text]

29. J.H. Yeon, N. Mazinani, T.S. Schlappi, K.Y.T. Chan, J.R. Baylis, S.A. Smith, A.J. Donovan, D. Kudela, G.D. Stucky, Y. Liu, J.H. Morrissey, C.J. Kastrup, “Localization of short-chain polyphosphate enhances its ability to clot flowing blood plasma”, Scientific Reports, 2017: 7: 42119. doi:10.1038/srep42119 [Full text]

28. E.L. Pryzdial, S.C. Meixner, K. Talbot, L.J. Eltringham-Smith, J.R. Baylis, F.M. Lee, C.J. Kastrup, W.F. Sheffield, “Thrombolysis by chemically modified coagulation factor Xa”, Journal of Thrombosis and Haemostasis,  2016: 14(9): 1866-1854. doi:10.1111/jth.13402 [Full text]

27. J.R. Baylis, A. Finkelstein-Kulka, L. Macias-Valle, J. Manji, M. Lee, E. Levchenko, C. Okpaleke, S. Al-Salihi, A. Javer, C.J. Kastrup, “Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid”, The Laryngoscope, 2016. doi:10.1002/lary.26408 [Full text]

26. J.R. Baylis, K.Y.T. Chan, C.J. Kastrup, “Halting hemorrhage with self-propelling particles and local drug delivery”, Thrombosis Research, 2016: 141(Suppl 2): S26-S39. doi: 10.1016/S0049-3848(16)30362-0 [Full text]

25. K.Y.T. Chan, C.Y. Zhao, E.M.J. Siren, J.C.Y. Chan, J. Boschman, C.J. Kastrup, “Adhesion of blood clots can be enhanced when copolymerized with a macromer that is cross-linked by coagulation factor XIIIa”, Biomacromolecules, 2016: 17(6): 248–2252. doi: 10.1021/acs.biomac.6b00481 [Full text]

24. J.R. Baylis, A.E. St. John, X. Wang, E.B. Lim, M.L. Statz, E. Simonson, S.A. Stern, R.T. Liggins, N.J. White, C.J. Kastrup, “Self-propelled dressings containing thrombin and tranexamic acid improve short-term survival in a swine model of lethal junctional hemorrhage”, Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, 2016: 46(3 Suppl 1): 123-128.  doi: 10.1097/SHK.0000000000000646. [Full text]

23. W.S. Hur, N. Mazinani, X.J.D. Lu, H.M. Britton, J.R. Byrnes, A.S. Wolberg, C.J. Kastrup, “Coagulation Factor XIIIa is Inactivated by Plasmin”, Blood, 2015: 126(20): 2329-2337. doi: 10.1182/blood-2015-07-650713 [Full text]

22. V. Chan, S.K. Novakowski, S. Law, C. Klein-Bosgoed, C.J. Kastrup, “Controlled transcription of exogenous mRNA in platelets using protocells”, Angewandte Chemie, 2015: 54(46):13590–13593. doi: 10.1002/anie.201506500 [Full text]

21. J.R. Baylis, J.H. Yeon, M.H. Thomson, A. Kazerooni, X Wang, A.E. St. John, E.B. Lim, D. Chien, A. Lee, J.Q. Zhang, J.M. Piret, L.S. Machan, T.F. Burke, H.J. White, C.J. Kastrup, “Self-Propelling Particles that Transport Cargo Through Flowing Blood and Halt Hemorrhaging”, Science Advances, 2015: 1(9), e1500379. doi: 10.1126/sciadv.1500379 [Full text]

20. J.H. Yeon, K.Y.T. Chan, T.C. Wong, K. Chan, M. R. Sutherland, R.F. Ismagilov, E.L.G. Pryzdial, C.J. Kastrup, “A biochemical network can control formation of a synthetic material by sensing numerous specific stimuli”, Scientific Reports, 2015: (5):10274. doi: 10.1038/srep10274. [Full text]

19. M. Kretschmer, E. Reiner, G. Hu, N. Tam, D.L. Oliveira, M. Caza, J.H. Yeon, J. Kim, C.J. Kastrup, W.H. Jung. J.W. Kronstad, “Defects in phosphate acquisition and storage influence the virulence of Cryptococcus neoformans”, Infection and Immunity, 2014: 2697-2712. [Full text]

18. C.J. Kastrup, M. Nahrendorf, J.L. Figueiredo, H. Lee, S. Kambhampati, T. Lee, S.W. Cho, R. Gorbatov, Y. Iwamoto, T.T. Dang, P. Dutta, J.H. Yeon, H. Cheng, C.D. Pritchard, A.J. Vegas, C.D. Siegel, S. MacDougall, M. Okonkwo, J.R. Stone, A.J. Coury, R. Weissleder, R. Langer, D.G. Anderson, “Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot”, Proceedings of the National Academy of Sciences. 2012 (109): 21444-9. [Full text]

17. A. Schroeder, M.S. Goldberg, C.J. Kastrup, Y. Wang, B.J. Joseph, C.G. Levins, R. Langer, D.G. Anderson, “Remotely-activated Protein-Producing Nanoparticles”, Nano Letters, 2012 (12):2685-2689. [Full text]

16. H. Cheng, M. Byrska-Bishop, C.T. Zhang, C.J. Kastrup, N.S. Hwang, W.W. Lee, X. Xu, M.P. Nahrendorf, R. Langer, D.G. Anderson, “Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics.”, Biomaterials, 2012 (33): 5004-12.

15. D. Chen, K. Love, Y. Chen, A. Eltoukhy, C.J. Kastrup, Christian; G. Sahay, A. Jeon, D. Yizhou, K. Whitehead, D.G. Anderson, “Rapid Discovery of Potent siRNA-Lipid-Nanoparticles Enabled by Controlled Microfluidic Formulation”, Journal of the American Chemical Society, 2012 (134): 6948-6951.

14. H. Cheng, C.J. Kastrup, R. Ramanathan, D.J. Siegwart, M.L. Ma, S.R. Bogatyrev, Q.B. Xu, K.A. Whitehead, R. Langer, D.G. Anderson, “Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery”, ACS Nano, 2010 (4): 625-631.

13. F. Shen, C.J. Kastrup, R.R. Pompano, R.F. Ismagilov, “Confinement Regulates Complex Biochemical Networks: Initiation of Blood Clotting by “Diffusion Acting”, Biophysical Journal, 2009 (97): 2137-2135.

12. C.J. Kastrup, J.Q. Boedicker, A.P. Pomerantsev, M. Moayeri, Y. Bian, R.R. Pompano, T.R. Kline, F. Shen, W.-J. Tang, S.H. Leppla, R.F. Ismagilov, “Spatial Localization of Bacteria Controls Initiation of Blood Coagulation by “Quorum Acting”, Nature Chemical Biology, 2008 (4): 742-750. [Full text]

11. F. Shen, C.J. Kastrup, Y. Liu, R.F. Ismagilov, “Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries is Controlled by Shear Rate”, Arteriosclerosis Thrombosis and Vascular Biology, 2008 (28): 2035-2041.

10. M.K. Runyon, C.J. Kastrup, B. Johnson-Kerner, T.G. Van Ha, R.F. Ismagilov, “The Effects of Shear Rate on Propagation of Blood Clotting Determined Using Microfluidics and Numerical Simulations” Journal of the American Chemical Society, 2008 (130): 3458-3464.

9. C.J. Kastrup, R.F. Ismagilov, “A physical-organic mechanistic approach to understanding the complex reaction network of hemostasis (blood clotting),” Journal of Physical Organic Chemistry, 2007 (20): 711-715.

8. C.J. Kastrup, M.K. Runyon, E.M. Lucchetta, R.F. Ismagilov, “Using Chemistry and Microfluidics to Understand the Spatial Dynamics of Complex Biological Networks” Accounts of Chemical Research, 2007 (41): 549-558.

7. C.J. Kastrup, F. Shen, R.F. Ismagilov, “Characterization of the Threshold Response of Initiation of Blood Clotting to Stimulus Patch Size,” Biophysical Journal, 2007 (93): 2969-2977.

6. M.K. Runyon, B. Johnson-Kerner, C.J. Kastrup, T.G. Van Ha, R.F. Ismagilov, “Simple Chemistry Identifies Mechanism for Localization of Blood Clots in Complex Network of Hemostasis,” Journal of the American Chemical Society, 2007 (129): 7014-7015.

5. C.J. Kastrup, F.Shen, R.F. Ismagilov, Response to shape emerges in a complex biochemical network and its simple chemical analogue. Angewandte Chemie International Edition, 2007 (46): 3660-3662.

4. C.J. Kastrup, M.K. Runyon, F.Shen, R.F. Ismagilov, “Modular Chemical Mechanism Predicts Spatiotemporal Dynamics of Initiation in the Complex Network of Hemostasis,” Proceedings of the National Academy of Sciences, 2006 (103): 15747-15752. [Full text]

3. C.J. Kastrup, S.V. Oldfield, H.S. Rzepa, “The aromaticity and Möbius characteristics of carbeno[8] heteroannulenes and triplet state annulenes,” Chemical Communications, 2002 (6): 642-643.

2. C.J. Kastrup, S.V. Oldfield, H.S. Rzepa, “An ab initio computational study of monodentate palladium ligand complexes with Mobius-aromatic chiral character,” Journal of the Chemical Society-Dalton Transactions, 2002 (12): 2421-2422.

1. W.L. Karney, C.J. Kastrup, S.V. Oldfield, H.S. Rzepa, “Möbius aromatic forms of 8-pi electron heteropine,” Journal of the Chemical Society-Perkin Transactions 2, 2002 (3): 388-392.